Title of article :
Prevalence of Protein-Energy Wasting and Its Association With Cardiovascular Disease Risk Factors in Iranian Peritoneal Dialysis Patients
Author/Authors :
As’habi, Atefeh School of Nutrition and Food Sciences - Semnan University of Medical Sciences - Semnan, Iran , Najafi, Iraj Department of Nephrology - Tehran University of Medical Sciences - Tehran, Iran , Tabibi, Hadi National Nutrition and Food Technology Research Institute, Faculty of Nutrition and Food Technology - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Hedayati, Mehdi Research Institute for Endocrine Sciences - Shahid Beheshti University of Medical Sciences - Tehran, Iran
Abstract :
Protein-energy wasting (PEW) is prevalent in dialysis
patients, and cardiovascular disease (CVD) is the leading cause
of mortality in these patients. This study aimed to determine the
prevalence of PEW and its relationship with CVD risk factors in
peritoneal dialysis (PD) patients in Tehran, Iran.
Materials and Methods. All eligible PD patients in Tehran peritoneal
dialysis centers were included in this cross-sectional study. The
diagnosis of PEW was done based on the criteria of the International
Society of Renal Nutrition and Metabolism. Serum high-sensitivity
C-reactive protein, soluble intercellular adhesion molecule type 1,
malondialdehyde, and lipid profile were measured.
Results. The prevalence of PEW was 29% in the PD patients.
Significant associations were found between the prevalence of
PEW in PD patients and sex (P = .01), age (P = .03), type of PD
dialysis solution (P = .04), and microinflammation (P = .03). Serum
C-reactive protein (P = .02), soluble intercellular adhesion molecule
type 1 (P = .001), and triglyceride (P = .03) were significantly higher
in the PD patients without PEW as compared to those with PEW,
whereas high-density lipoprotein cholesterol level was significantly
lower in the PD patients without PEW as compared to those with
PEW (P = .003).
Conclusions. Our study shows that PEW is prevalent in Iranian PD
patients. In addition, serum concentrations of CVD risk factors are
dependent on the amount of glucose absorbed from PD solutions
and are more impaired in PD patients without PEW as compared
to those with PEW.
Keywords :
cardiovascular disease risk factors , peritoneal dialysis , Iran , protein-energy wasting
Journal title :
Astroparticle Physics