Author/Authors :
sefati, niloofar Department of Biology and Anatomical Sciences - School of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran , abbaszadeh, hojjat allah Department of Biology and Anatomical Sciences - School of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Fadaei Fathabady, fatemeh Department of Biology and Anatomical Sciences - School of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Abdollahifar, Mohammad-Amin Department of Biology and Anatomical Sciences - School of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran , amini, abdollah Department of Biology and Anatomical Sciences - School of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran , norouzian, mohsen Department of Biology and Anatomical Sciences - School of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran , noori zadeh, ali Department of Clinical Biochemistry - Faculty of Paramedicine - Ilam University of Medical Sciences, Ilam, Iran , darabi, shahram Cellular and Molecular Research Center - Qazvin University of Medical Science, Qazvin, Iran
Abstract :
Introduction: Several experimental studies have displayed positive result for laser radiation on stimulating bone regeneration in recent years. The purpose of this experimental study was to determine low-level laser (LLL) effects on partial bone defects in hypothyroidism male rat.
Methods: Forty male Wistar rats were randomly distributed as below groups: hypothyroidism + laser (Hypo + laser), hypothyroidism (Hypo), and control. Four weeks after surgery, the tibia bone was removed. Biomechanical and histological examinations were performed immediately.
Results: Our results showed significant reduction in the absorption of energy, resistance in bending deformation (bending stiffness), maximum force, high stress load, trabecular bone volume, and number of osteocytes, osteoblasts and osteoclasts in the osteotomy site in hypothyroidism rats compared to hypothyroidism + laser group (P < 0.05).
Conclusion: The results indicated that using laser may improve fracture regeneration and it may accelerate bone healing in hypothyroidism rat.
