Three Months Aerobic Training Cannot Modulate C-Terminal Telopeptide of Type 1 Collagen in Cigarette Smokers

background: osteoporosis, as an important public health problem, is associated with cigarette smoking.objectives: the present study aimed to evaluate the impact of 3 months supervised aerobic training program on c-terminal telopeptide of type 1 collagen (ctx) as a marker of bone resorption in male smokers.methods: in this semi-experimental study, thirty-two sedentary adult male smokers (winter 2016, saveh, iran) aged 42 ± 7 years were randomly assigned to exercise group (3 months aerobic training, 3 times/weekly at 60% - 75% of maximum heart rate, n = 16) or control group (no training, n = 16). serum calcium, ctx and anthropometrical markers at before and after training were determined in exercise and control subjects. the statistical significance of the changes was evaluated by student’s t-test. the changes less than 0.05 were considered statistically significant.results: a significant decrease was observed in anthropometrical markers by aerobic training in the exercise group (p < 0.05). no significant changes were observed for serum calcium (p = 0.126) and ctx (p = 0.835) after aerobic intervention compared with baseline levels. no significant changes were observed in all variables in the control group (p ≥ 0.05).conclusions: these data suggest that aerobic training with mentioned details cannot improve bone resorption with emphasis on ctx in male smokers. to achieve a better conclusion, it is necessary to assess the indicative markers of both bone resorption and formation in response to exercise.