Title of article :
Microbial Alpha-Amylase Production: Progress, Challenges and Perspectives
Author/Authors :
Elyasi Far, Babak Drug Applied Research Center - Tabriz University of Medical Sciences - Department of Pharmaceutical Biotechnology - Faculty of Pharmacy - Tabriz University of Medical Sciences , Ahmadi, Yassin Student Research Committee - Tabriz University of Medical Sciences , Yari Khosroushahi, Ahmad Department of Medical Nanotechnology - Faculty of Advanced Medical Science - Tabriz University of Medical Sciences - Drug Applied Research Center - Tabriz University of Medical Sciences , Dilmaghani, Azita Drug Applied Research Center - Tabriz University of Medical Sciences - Department of Pharmaceutical Biotechnology - Faculty of Pharmacy - Tabriz University of Medical Sciences
Abstract :
Alpha-amylase reputes for starch modification by breaking of 1-4 glycosidic bands and is widely applied in different industrial sectors. Microorganisms express unique alpha-amylases
with thermostable and halotolerant characteristics dependent on the microorganism’s intrinsic
features. Likewise, genetic engineering methods are applied to produce enzymes with higher
stability in contrast to wild types. As there are widespread application of α-amylase in industry,
optimization methods like RSM are used to improve the production of the enzyme ex vivo.
This study aimed to review the latest researches on the production improvement and stability
of α-amylase.
Keywords :
Microbial , Alpha-amylase , RMS , Stability , Optimization
Journal title :
Advanced Pharmaceutical Bulletin
