Title of article :
Predictive value of pregnancy-associated plasma protein-A in relation to fetal loss: A systematic review and meta-analysis
Author/Authors :
Hadizadeh-Talasaz ، Zahra Student Research Committee - Mashhad University of Medical Sciences , Taghipour ، Ali Department of Epidemiology - Social Determinants of Health Research Center, School of Health - Mashhad University of Medical Sciences , Mousavi-Vahed ، Houra Department of Obstetrics and Gynecology - Faculty of Medicine - Mashhad University of Medical Sciences , Latifnejad Roudsari ، Robab Department of Midwifery - Nursing and Midwifery Care Research Centre, School of Nursing and Midwifery - Mashhad University of Medical Sciences
From page :
395
To page :
406
Abstract :
Background: For a woman with bleeding and threatened abortion, ultrasound scan is done to confirm the viability of the fetus; however, 1015% of the embryos are eventually aborted. Distinguishing between women with good and poor prognosis can be a helpful approach. Objective: This study aimed to review the predictive value of Pregnancyassociated Plasma Protein A (PAPPA) in relation to the diagnosis of fetal loss. Materials and Methods: The articles published in multiple databases including Web of Science, PubMed, MEDLINE, Scopus, and Persian databases such as ISC, Magiran, and IranMedx were searched for articles published until May 2019. MeSH terms was used for searching the databases including fetal loss OR pregnancy loss OR abortion OR miscarriage with the following word using AND; PregnancyAssociated Plasma ProteinA OR PAPPA. Two reviewers extracted data and recorded them in a predefined form and assessed the quality of articles using the NewcastleOttawa tool. Metaanalysis was done using the Comprehensive MetaAnalysis/2.0 software and MetaDisc. Results: A total number of 16 studies were eligible for the qualitative data synthesis, out of which 8 studies were included in the metaanalysis. All studies had high and medium quality. The forest plot analysis showed a sensitivity of 57% (95% CI: 53-63%), a specificity of 83% (95% CI: 80-85%), a positive likelihood ratio of 3.52 (95% CI: 2.44-5.07), a negative likelihood ratio of 0.54 (95% CI: 0.37-0.79), and a diagnostic odds ratio of 6.95 (95% CI: 3.58-13.50). Conclusion: PAPP-A cannot be recommended on a routine basis for predicting fetal loss and still further research with a combination of other biomarkers is required.
Keywords :
Pregnancy , associated plasma protein , A , Fetal loss , Pregnancy , Systematic review
Journal title :
International Journal of Reproductive BioMedicine
Journal title :
International Journal of Reproductive BioMedicine
Record number :
2512144
Link To Document :
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