Title of article :
Biotransformation of danazol by Fusarium solani and Gibberella fujikuorii, and prolyl endopeptidase inhibition studies of transformed products
Author/Authors :
AZIZUDDIN Federal Urdu University for Arts, Science Technology,Gulshan-e-Iqbal Campus - Department of Chemistry, PAKISTAN , CHOUDHARY, Muhammad Iqbal University of Karachi - International Center for Chemical and Biological Sciences, H E J Research Institute of Chemistry, PAKISTAN
Abstract :
Biotransformation of danazol (17β -hydroxy-17α-pregna-2,4-dien-20-yno-[2,3-d] isoxazole) (1) on fermentation with Fusarium solani yielded 17β -hydroxy-2-(hydroxymethyl)-17α-pregn-4-en-20-yn-3-one (2) and 17β -hydroxy-2-(hydroxymethyl)-17α-pregna-1,4-dien-20-yn-3-one (3), while the fermentation of 1 with Gibberella fujikuorii yielded compound 2 only. The structures of these compounds were deduced on the basis of modern spectroscopic techniques. Prolyl endopeptidase inhibition activities of danazol (1) and its transformed products 2 and 3 are also studied.
Keywords :
Biotransformation , danazol , Fusarium solani , Gibberella fujikuorii , prolyl endopeptidase (PEP) inhibition assay
Journal title :
Turkish Journal of Chemistry
Journal title :
Turkish Journal of Chemistry