Trichloroacetic Acid Peel 15% + NB-UVB Versus Trichloroacetic Acid Peel 25% + NB-UVB for Stable Non-Segmental Vitiligo

Background: No single treatment proved to be satisfactory for vitiligo, therefore, dermatologists are still searching for innovative therapeutics and combinations. Objectives: To evaluate the efficacy of combined trichloroacetic acid peel 15% (TCA) +NB-UVB versus TCA 25% + NB-UVB for cases with stable, non-segmental vitiligo. Patients and Methods: Ten patients with stable, nonsegmental and non-acral vitiligo were recruited. Two lesions per patient were treated: The 1st with TCA 15% + NB-UVB, whereas, the 2nd with TCA 25% + NB-UVB. Clinical assessment was done before and after treatment. Results: The 1^st lesions treated with TCA 15% + NBUVB showed marked improvement in 70% of patients, moderate improvement in 10% and minimal response in 20%. While the 2^nd treated lesions with TCA 25% + NB-UVB revealed marked improvement in 20% of patients, moderate improvement in 40%, mild improvement in 10% and minimal in 30%. No koebneriation or disease activation has been Conclusion: Initiation of vitiligo therapy with TCA 15% can enhance the clinical response achieved by NB-UVB. Recommendations: TCA should be tried on a large scale of patients as monotherapy and combined therapy.