Title of article :
Solvent Free Synthesis of tetra alkyl- phenyl-1H-pyrimido [4, 5-e][1,3,4]Thiadiazine-3,7-diamines
Author/Authors :
Mohammadi, Mohammad Kazem Department of chemistry - Islamic Azad University Ahvaz Branch, Ahvaz, Iran
Abstract :
New 1,5-tetra alkyl methyl- phenyl-1H-pyrimido[4,5-e][1,3,4]thiadiazine-3,7-diamine were synthesized via the cyclocondensation of 2-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-2-methylhydrazine with phenylthioisothiocyanate and further replacement of chlorine atom on the seven number position of pyrimido[4, 5- e][1, 3, 4]thiadiazin by appropriate secondary amines in simple and efficient methods.
Keywords :
heterocyclization , 5- bromo- 2,4- dichloro-6- methylpyrimidine , 2-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-2-methylhydrazine , phenylthioisothiocyanate
Journal title :
International Journal of Heterocyclic Chemistry
