Title of article :
The Power of Classic Music to Reduce Anxiety in Rats Treated with Simvastatin
Author/Authors :
da cruz, j.n. universidade do extremo sul catarinense, Brazil , de lima, d.d. universidade da região de joinville, Brazil , dal magro, d.d. universidade regional de blumenau, Brazil , da cruz, j.g.p. department of natural sciences, universidade regional de blumenau, Brazil
Abstract :
Introduction: This study was designed to investigate the effects of music in Wistar rats after sub-chronic treatment of simvastatin. Methods: The rats were orally administered with either simvastatin or saline (controls). After 4 weeks of drug treatment, the rats were selected for behavioral studies. The rats were exposed to music 24 hours before behavioral tests (Mozart s piano sonata, KV361, Largo). Results: The experiments suggest that exposure to chronic treatment with simvastatin (1 or 10 mg/kg/day) reduced anxiety levels in rats when associated with Mozart music in an elevated plus-maze. Discussion: These results indicate that music can serve as an effective adjuvant in rats treated with simvastatin, and that this species could potentially be used in other preclinical models utilizing musical interventions.
Keywords :
Elevated plus , maze , Music , Open , field , Rattus norvegicus , Simvastatin
Journal title :
Basic and Clinical Neuroscience
Journal title :
Basic and Clinical Neuroscience
