Author/Authors :
ABDULLAH, WAN OMAR Universiti Putra Malaysia - Faculty of Medicine and Health Sciences - Department of Medical Microbiology Parasitology, Malaysia , UNYAH, NGAH ZASMY Universiti Putra Malaysia - Faculty of Medicine and Health Sciences - Department of Medical Microbiology Parasitology, Malaysia , HAMAT, RUKMAN AWANG Universiti Putra Malaysia - Faculty of Medicine and Health Sciences - Department of Medical Microbiology Parasitology, Malaysia , OMAR, BAHARUDIN Universiti Kebangsaan Malaysia - Faculty of Health Sciences - Department of Biomedical Science, Malaysia , ABD GHANI, MOHAMED KAMEL Universiti Kebangsaan Malaysia - Faculty of Health Sciences - Department of Biomedical Science, Malaysia , RAYANI, MOHAMMAD shiraz university of medical sciences - School of Medicine - Department of Parasitology and Mycology, شيراز, ايران , HATAM, GHOLAM REZA shiraz university of medical sciences - School of Medicine - Department of Parasitology and Mycology, شيراز, ايران
Abstract :
Dichloromethane and methanolic extracts of each plant were tested for their antiplasmodial activity on chloroquine- resistant strain of Plasmodium falciparum (FCB strain), based on lactate dehydrogenase activity. Cytotoxicity was assessed with the MTT test on MRC-5 human diploid embryonic lung cells. Most extracts of ten selected plants used in Malay traditional medicine in Malaysia had activity in vitro. This supports continued investigations of traditional medicine in the search for new antimalarial agent. The compounds responsible for the observed antiplasmodial effects are under investigation.
Keywords :
Plasmodium falciparum , Plant , Antiplasmodial activity , Cytotoxicity , Malaysia.
