Title of article
ANTINEOPLASTIC ACTIVITY OF NICKEL (II)-CYSTINE COMPLEX AGAINST EHRLICH ASCITES CARCINOMA IN SWISS ALBINO MICE
Author/Authors
JESMIN, M. University of Rajshahi - Department of Applied Chemistry and Chemical Technology, Bangldesh , ALI, M.M. University of Rajshahi - Department of Applied Chemistry and Chemical Technology, Bangldesh , BISWAS, A. K. University of Rajshahi - Department of Applied Chemistry and Chemical Technology, Bangldesh , HABIB, M. R. University of Rajshahi - Department of Biochemistry and Molecular Biology, Bangldesh , KHANAM, J. A. University of Rajshahi - Department of Biochemistry and Molecular Biology, Bangldesh
From page
135
To page
142
Abstract
Ni(II)-cystine complex was synthesized by treating saturated aqueous solutions of Ni (II) acetate and L(-) cystine (in 1: 1 molar ratio). The complex was used to study its antineoplastic activity against EAC cells in Swiss Albino mice. It was found that the Ni (II) complex restored the depleted haematological and biochemical parameters of the EAC bearing mice towards normal values and enhanced the longevity of such mice significantly. The test compound on the other hand showed negligible host toxicity. The results obtained were compared with those obtained with a standard anticancer drug bleomycin.
Keywords
Antineoplastic activity , Ehrlich Ascites Carcinoma , Ni(II) cystine complex
Journal title
Medical Journal of Islamic World Academy of Sciences
Journal title
Medical Journal of Islamic World Academy of Sciences
Record number
2575365
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