Title of article :
Independent Regulation of Na+ and K+ Balance by the Kidney
Author/Authors :
Castañeda-Bueno, María Universidad Nacional Autónoma de México - Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Instituto Nacional de Cardiología Ignacio Chávez, and Instituto de Investigaciones Biomédicas - Molecular Physiology Unit, Mexico , Arroyo, Juan Pablo Universidad Nacional Autónoma de México - Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Instituto Nacional de Cardiología Ignacio Chávez, and Instituto de Investigaciones Biomédicas - Molecular Physiology Unit, Mexico , Gamba, Gerardo Universidad Nacional Autónoma de México - Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Instituto Nacional de Cardiología Ignacio Chávez, and Instituto de Investigaciones Biomédicas - Molecular Physiology Unit, Mexico
Abstract :
The understanding of the independent regulation of sodium and potassium by the kidney has remained elusive. Recent evidence now points to dissimilar regulatory mechanisms in ion handling, dependent on the presence of either aldosterone alone or angiotensin II with aldosterone among other factors. This review summarizes past and present information in an attempt to reconcile the current concepts of differential regulation of sodium and potassium balance through the with-no-lysine (K) kinase (WNK) system and the previous knowledge regarding ion transport mechanisms in the distal nephron.
Keywords :
Angiotensin II , Aldosterone , Sodium balance , Potassium balance , Na+ , Cl , cotransporter , Renal outer medullary K+ channel , Apical Na+ channel , WNK kinases
Journal title :
Medical Principles and Practice
Journal title :
Medical Principles and Practice
