Title of article :
Microwave-Assisted Synthesis and Antioxidant Properties of Some New 1,2,4-Triazole Derivatives
Author/Authors :
Al-Soud, Yaseen A. University of Al-al-Bayt - Faculty of Science - Department of Chemistry, Jordan , Mohammed, Hamdoon A. Al-Azhar University - Faculty of Pharmacy - Department of Pharmacognosy, Egypt , Abo-Amer, Anwar University of Al-al-Bayt - Faculty of Science - Department of Chemistry, Jordan
Abstract :
A series of new 5-(substituted biphenyl-4-yl)-3-(methoxyphenyl)-1-methyl-1H-1,2,4-triazoles (5-15) were successfully synthesized by Suzuki coupling between 5-(4-bromophenyl)-3-(substituted methoxyphenyl)-1-methyl-1H-1,2,4-triazoles (3 and 4), which were used as key intermediates for the synthesis of our targets, and the appropriate boronic acid. The new synthesized compounds were characterized by 1H, 13C-NMR and mass spectrometry. The antioxidant properties of the newly synthesized 1,2,4-triazoles have been studied for their antioxidative activity using metal ions (Fe^3+ , Cu^2+ ) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging. Compound 14 showed the highest antioxidant activity.
Keywords :
1,2,4 , triazoles , Microwave , Assisted Synthesis , Antioxidant
Journal title :
Jordan Journal of Chemistry
Journal title :
Jordan Journal of Chemistry
