Author/Authors :
Mahmoud, Heba Uallah R. Physiology Division - Zoology Department - Faculty of Science - Beni-Suef University, Beni-Suef, Egypt , Ahmed, Osama M. Physiology Division - Zoology Department - Faculty of Science - Beni-Suef University, Beni-Suef, Egypt , Fah, Hanaa I. Physiology Division - Zoology Department - Faculty of Science - Beni-Suef University, Beni-Suef, Egypt , Ahmed, Noha A. Physiology Division - Zoology Department - Faculty of Science - Beni-Suef University, Beni-Suef, Egypt , Ashou, Mohamed B. Physiology Division - Zoology Department - Faculty of Science - Beni-Suef University, Beni-Suef, Egypt
Abstract :
This study aims to assess the preventive effects of rutin and/or quercetin on doxorubicin-induced kidney
and heart injuries and oxidative stress in male Wistar rats. The male Wistar rats, injected with doxorubicin at an
intraperitoneal dose 2 mg/kg b.w. 2 days per week for 5 weeks, were orally treated with rutin and/or quercetin with
dose level 50 mg /kg b.w. every other day for 5weeks. The treatments of doxorubicin-injected rats with rutin, quercetin
and their combination resulted in a significant decrease in the elevated serum creatinine and urea levels reflecting
an improvement in kidney function. Similarly, the elevated serum CK-MB and LDH activities were significantly
ameliorated as a result of treatments of doxorubicin-injected rats, thereby manifesting an amendment of heart function.
The treatments also led to the prevention of the elevated lipid peroxidation and amelioration of the lowered GPx,
GST and SOD activities as well as GSH content in kidney and heart as a result of treatment of doxorubicin-injected
rats with rutin and quercetin. Also, the treatments remarkably improved doxorubicin-induced deleterious histological
alterations in kidney and heart. In conclusion, rutin and/or quercetin may have chemopreventive potentials against
doxorubicin-induced nephrocardiotoxicity via suppression of oxidative stress and enhancement of antioxidant defense
system.
Keywords :
Rutin , Quercetin , Doxorubicin , Kidney , Heart , Oxidative stress