Clinical Evidence: The Prolonged Dust Exposure The Disorder In Serum Oxidant - Antioxidant Balance

Dust can be considered as an important factor in environmental pollution which has a dircct effect on human health. In this study ,wc attempted to evaluate serum oxidant -antioxidant balancc in workers dust exposed continuously and also the effect of iron and silicon content in exposed dust on the mentioned balance .The study included three groups: A group included 20 workers of building block factories, B group included 20 workers in general company of grains production and C group included 15 healthy subjects which represented control group. Iron and silicon contents in dust samples of two studied regions were measured. Higher levels of iron and silicon were found in A group region compared to B group region. Our results illustrated a significant elevation in serum (MDA) levcl(thc index of lipid peroxidation) for A group compared to Band C groups. Also, a significant decrease in serum albumin level was found in A group compared to C group as well as scrum ceruloplasmin level in A group was found to be significantly elevated compared to B and C groups. A negative correlation was found between scrum MDA and scrum albumin levels in A and B groups. Also .positive correlations were found between serum MDA and each of serum ceruloplasmin and daily dust exposure time in A and B groups. These results provide a new conclusion that the iron and silicon content in prolonged exposed dust lead to disorder in serum oxidant - antioxidant balance.