Author/Authors :
Dombai, Brigitta Department of Pulmonology - Semmelweis University, Budapest, Hungary , Ivancsó, István Klinik fur An asthesie - Kantonsspital Aarau, Aarau, Switzerland , Bikov, András Department of Pulmonology - Semmelweis University, Budapest, Hungary , Oroszi, Dóra Department of Pulmonology - Semmelweis University, Budapest, Hungary , Bohács, Anikó Department of Pulmonology - Semmelweis University, Budapest, Hungary , Müller, Veronika Department of Pulmonology - Semmelweis University, Budapest, Hungary , János, Rigó Jr. 1st Department of Obstetrics and Gynecology - Semmelweis University, Budapest, Hungary , Vásárhelyi, Barna Department of Laboratory Medicine - Semmelweis University, Budapest, Hungary , Losonczy, György Department of Pulmonology - Semmelweis University, Budapest, Hungary , Tamási, Lilla Department of Pulmonology - Semmelweis University, Budapest, Hungary
Abstract :
Asthma in pregnancy poses a risk of adverse outcomes. Osteopontin and clusterin emerged as asthma biomarkers; however, their
circulating levels during pregnancy are unknown yet. This cross-sectional study investigated peripheral osteopontin and clusterin
levels and their relationship to disease control in 26 asthmatic pregnant (AP), 22 asthmatic nonpregnant (ANP), and 25 healthy
pregnant (HP) women and 12 healthy controls (HNP). Osteopontin levels of ANP and HNP were similar (2.142 [1.483–2.701] versus
2.075 [1.680–2.331] ng/mL, 𝑝 = 0.7331). Pregnancy caused a marked elevation in both healthy (HP: 3.037 [2.439–4.015] ng/ml, 𝑝 =
0.003 versus HNP) and asthmatic (AP: 2.693 [1.581–3.620] ng/ml) patients; thus the pregnant groups did not differ (𝑝 = 0.3541).
Circulating clusterin levels were comparable in ANP and HNP (109.2 [95.59–116.3] versus 108.8 [97.94–115.3] 𝜇g/mL, 𝑝 = 0.8730)
and the level was lower in HP (98.80 [84.26–105.5] 𝜇g/mL, 𝑝 = 0.0344 versus HNP). In contrast, the level was higher in AP (111.7
[98.84–125.6] 𝜇g/mL, 𝑝 = 0.0091 versus HP). In ANP, a positive correlation of PEF (𝑟 = 0.3405; 𝑝 = 0.0221) and a negative
correlation of 𝑅aw (𝑟 = −0.3723; 𝑝 = 0.0128) to clusterin level were detected. Circulating osteopontin level increases in pregnancy
regardless of concomitant well-controlled asthma, indicating its gestational role. Clusterin level decreases in healthy but not in
asthmatic pregnancy and correlates directly with lung function.
