A Case of Cardiac Tamponade in a Patient with Metastatic RenalCell Carcinoma on Pazopanib Treatment

Asymptomatic minimal pericardial effusion may be frequently found in patients with hypothyroidism. Cardiac tamponadesecondary to hypothyroidism is rarely referenced in medical literature. Hypothyroidism as an adverse effect of pazopanib(tyrosine kinase inhibitor) treatment leading to cardiac tamponade is an even rarer occurrence. Here, we report an unusual caseof a 71-year-old male, with a case of renal cell carcinoma on pazopanib treatment presenting with shortness of breath who wasfound to have hypothyroidism with a large pericardial effusion leading to cardiac tamponade. The patient did not have anyprior reports of thyroid-stimulating hormone (TSH) or thyroid hormone levels at presentation. No such case of cardiactamponade due to hypothyroidism as an adverse effect of pazopanib tablet treatment has been reported to our knowledge.