Author/Authors :
Wang, Xiaoyun Taiyuan University of Technology - Taiyuan - Shanxi, China , Zhao, Min Taiyuan University of Technology - Taiyuan - Shanxi, China , Wang, Xiaoqiang Department of Scientifc Computing - Florida State University - Tallahassee, USA , Li, Shuping Department of Mathematics - North University of China - Taiyuan - Shanxi, China , Cao, Ning Department of Physiology and Pathophysiology - School of Basic Medical Sciences - Capital Medical University - Beijing, China , Liu, Huirong Department of Physiology and Pathophysiology - School of Basic Medical Sciences - Capital Medical University - Beijing, China
Abstract :
High titer of B1-adrenoreceptor autoantibodies (B1-AA) has been reported to appear in heart failure patients. It induces sustained
B1-adrenergic receptor (B1-AR) activation which leads to heart failure (HF), but the mechanism is as yet unclear. In order to
investigate the mechanisms causing B1-AR non-desensitization, we studied the beatingfrequency of the neonatal rat cardiomyocytes
(NRCMs) under diferent conditions (an injection of isoprenaline (ISO) for one group and B1-AA for the other) and established
three dynamic models in order to best describe the true relationships shown in medical experiments; one model used a control
group of healthy rats; then in HF rats one focused on conformation changes in B1-AR; the other examined interaction between
B1-AR and B2-adrenergic receptors (B2-AR). Comparing the experimental data and corresponding Akaike information criterion
(AIC) values, we concluded that the interaction model was the most likely mechanism. We used mathematical methods to explore
the mechanism for the development of heart failure and to fnd potential targets for prevention and treatment. Te aim of the
paper was to provide a strong theoretical basis for the clinical development of personalized treatment programs. We also carried
out sensitivity analysis of the initial concentration B1-AA and found that they had a noticeable efect on the ftting results
