Author/Authors :
Sasapu, Appalanaidu Department of Medicine - Division of Hematology Oncology - University of Arkansas for Medical Science - Little Rock - AR, USA , Socola, Francisco Department of Medicine - Division of Hematology Oncology - University of Arkansas for Medical Science - Little Rock - AR, USA , Atrash, Shebli Department of Medicine - Division of Hematology Oncology - University of Arkansas for Medical Science - Little Rock - AR, USA , Insuasti-Beltran, Giovanni Department of Hematopathology/Molecular Genetics Pathology - University of Arkansas for Medical Sciences - Little Rock - AR, USA , Lobo, Rodolfo Henrich Department of Hematopathology/Molecular Genetics Pathology - University of Arkansas for Medical Sciences - Little Rock - AR, USA
Abstract :
We report the case of a young African American male with nosignificant past medical history presenting with low backand bilateral leg pain; presenting CBC and chemistries revealed elevated white blood cell count of 250,000, with anemia (Hb6.8 g/dL) and thrombocytopenia (platelets 9 K/𝜇L), and elevated LDH, 1008. Physical examination findings were notable for diffuselymphadenopathy and lower extremity skin nodules. Interestingly the bone marrow biopsy revealed involvement by CLL/SLL withtranslocation (2;14)(p16;q32) and trisomy 12. The patient was treated with fludarabine-based chemotherapy and steroids for CLL-related ITP with excellent response. After three cycles of chemotherapy, all the enlarged lymph nodes and skin nodules disappeared,and patient had achieved complete hematologic response. In this paper we also reviewed the available literature of CLL patientswith translocation (2;14).