Author/Authors :
Gzgzyan, Alexandr Department of Assisted Reproduction Technologies - FSBI D. O. Ott Research Institute of Obstetrics - Gynecology and Reproductology - Saint Petersburg, Russia , Muller, Valeria Department of Assisted Reproduction Technologies - FSBI D. O. Ott Research Institute of Obstetrics - Gynecology and Reproductology - Saint Petersburg, Russia , Ob’edkova, Ksenia Department of Assisted Reproduction Technologies - FSBI D. O. Ott Research Institute of Obstetrics - Gynecology and Reproductology - Saint Petersburg, Russia , Krikheli, Inna Department of Assisted Reproduction Technologies - FSBI D. O. Ott Research Institute of Obstetrics - Gynecology and Reproductology - Saint Petersburg, Russia , Kogan, Igor Department of Assisted Reproduction Technologies - FSBI D. O. Ott Research Institute of Obstetrics - Gynecology and Reproductology - Saint Petersburg, Russia , Fedorova, Irina Department of Assisted Reproduction Technologies - FSBI D. O. Ott Research Institute of Obstetrics - Gynecology and Reproductology - Saint Petersburg, Russia , Lesik, Elena Department of Assisted Reproduction Technologies - FSBI D. O. Ott Research Institute of Obstetrics - Gynecology and Reproductology - Saint Petersburg, Russia , Komarova, Evgenia Department of Assisted Reproduction Technologies - FSBI D. O. Ott Research Institute of Obstetrics - Gynecology and Reproductology - Saint Petersburg, Russia
Abstract :
We report three cases of effective management of infertility in women with a history of repeated unsuccessful IVF attempts, whohave developed antibodies to hCG. A novel approach to conservative treatment of immunologic reproductive failure, suggestedfor selected patients, included membrane plasmapheresis, combined prednisolone, and intravenous immunoglobulin therapy. Noadverse side effects were observed; all cases resulted in pregnancy and subsequent life births. In order to be given an adequateefficient treatment, women with recurrent implantation failure should be suspected for autoimmune factor of infertility and itspossible association with anti-hCG autoimmunity.
Keywords :
Successful Pregnancy Outcome , Women , Recurrent IVFF ailure , Anti-hCG Autoimmunity , anti-hCG
