Author/Authors :
Ribeiro, Rubens Fernando Gonçalves Universidade Estadual do Para (UEPA), Brazil , Couteiro, Rodrigo Paracampo School of Medicine - UEPA, Belem-PA, Brazil , Monteiro, Andrew Moraes School of Medicine - UEPA, Belem-PA, Brazil , Rodrigues, Ivone Aline da Silva School of Medicine - UEPA, Belem-PA, Brazil , Cavalcante, Lainy Carollyne da Costa School of Medicine - Centro Universitário do Estado do Pará (CESUPA), Brazil , Gouveia, Eduardo Henrique Herbster School of Medicine - Centro Universitário do Estado do Pará (CESUPA), Brazil , Galvão, Lucas Nascimento School of Medicine - Centro Universitário do Estado do Pará (CESUPA), Brazil , Lopes, Luiz Renato Oliveira School of Medicine - UEPA, Belem-PA, Brazil , Yasojima, Edson Yuzur Department of Experimental Surgery - UEPA, Belem-PA, Brazil , Brito, Marcus Vinicius Henriques Department of Experimental Surgery - UEPA, Belem-PA, Brazil
Abstract :
Purpose:
To evaluate the effects of hypertonic saline solution associated to remote ischemic perconditioning in liver ischemia/reperfusion injury in rats.
Methods:
25 male rats (Wistar) were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of liver ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during liver ischemia; Hypertonic saline solution group (HSS) treated with hypertonic saline solution (4ml/kg); Remote ischemic perconditioning + Hypertonic saline solution group (Per+HSS) with both treatments.
Results:
Per+HSS group showed a lower degree of liver dysfunction in relation to I/R group, whereas the technique of remote ischemic perconditioning isolated or associated with saline solution significantly improved liver function and reduced histological damage.
Conclusion:
Remote ischemic perconditioning associated or not to saline solution promoted reduction of acute liver injury induced by ischemia/reperfusion.
Keywords :
Ischemia , Reperfusion , Saline Solution , Hypertonic , Liver , Rats
