Author/Authors :
Giudice, Amerigo Department of Health Sciences - School of Dentistry - Magna Graecia University of Catanzaro, Catanzaro, Italy , Liborio, Francesco Department of Health Sciences - School of Dentistry - Magna Graecia University of Catanzaro, Catanzaro, Italy , Averta, Fiorella Department of Health Sciences - School of Dentistry - Magna Graecia University of Catanzaro, Catanzaro, Italy , Barone, Selene Department of Health Sciences - School of Dentistry - Magna Graecia University of Catanzaro, Catanzaro, Italy , Fortunato, Leonzio Department of Health Sciences - School of Dentistry - Magna Graecia University of Catanzaro, Catanzaro, Italy
Abstract :
Oral lichenoid reactions (OLR) can be caused by systemic drug exposure. To the best of our knowledge, this is the second report
describing a case of OLR induced by rituximab administration in a patient with a diagnosis of non-Hodgkin B-cell lymphoma.
After 5 doses of rituximab, a typical pattern of OLP was identified with bilateral and symmetrical lesions on the buccal mucosa
and on the right lingual margin. This temporal relationship suggested a probable association between oral lesions and drug
therapy. The clinical diagnosis of a rituximab-induced OLR was confirmed by an incisional biopsy reporting a histopathological
result of lichenoid mucositis consistent with oral lichen planus. Because of the increasing use of rituximab, it is necessary to
know and recognize this uncommon side effect.
