Author/Authors :
Zare Mahmood Abadi, Reza mashhad university of medical sciences - Faculty of Dentistry, Dental Research Center - Department of Oral Maxillofacial Pathology, ايران , Sharifi Sistani, Noorieh mashhad university of medical sciences - Quaem Hospital - Department of Clinico Anatomical Pathology, ايران , Mohtasham, Nooshin mashhad university of medical sciences - Faculty of Dentistry, Dental Research Center - Department of Oral Maxillofacial Pathology, ايران , Kamyab Hesari, Kambiz tehran university of medical sciences tums - Razi Hospital - Department of Dermatopathology, تهران, ايران , Vaezi, Tooraj mashhad university of medical sciences - Faculty of Dentistry, Dental Research Center - Department of Oral Maxillofacial Pathology, ايران , Pazouki, Mahdi mashhad university of medical sciences - Faculty of Dentistry, Dental Research Center - Department of Oral Maxillofacial Pathology, ايران , Taghi Shakeri, Mohammad mashhad university of medical sciences - Medical School - Department of Community Medicine, ايران
Abstract :
Objectives: To investigate the frequency and possible role of Epstein-Barr virus infection in non-Hodgkin s lymphomas of the oral cavity and maxillofacial region in Khorasan (Northeast of Iran).Methods: The cross-sectional retrospective study assessed the frequency of Epstein-Barr virus infection in nonimmunosuppressed non-Hodgkin s lymphoma cases of the oral cavity and maxillofacial region. Formalin-fixed, paraffin-embedded tissue sections from 34 cases of head and neck non-Hodgkin s lymphoma (17 low-grade B-cell lymphoma, 14 diffuse large B-cell lymphoma, and 3 peripheral T cell lymphoma) were selected as a case group, and 10 normal lymph node sections were considered as a control group. Polymerase chain reaction was used to detect the EBV-DNA in tissue specimens. SPSS 16 was used for statistical analysis of the data. Results: EBV-DNA was detected in 26.5% of NHL samples. Among NHLs, Epstein-Barr virus was found to be positive in 50% cases with diffuse large B-cell lymphoma and 11.8% of low grade B-cell lymphomas. Epstein-Barr virus was not detected in any cases of peripheral T-cell lymphoma. Conclusion: Although it seems that Epstein-Barr virus appears to be an etiological factor in some subtypes of non- Hodgkin s lymphomas, especially in diffuse large B-cell lymphoma, more researches should be done to investigate the relationship between Epstein-Barr virus infection and head and neck non-Hodgkin s lymphomas.
Keywords :
Non Hodgkin Lymphoma , Epstein , Barr virus , head and neck lymphomas , Khorasan , Iran.
