Title of article :
Medroxyprogesterone Acetate and Progesterone, Used Short Term, Do not Adversely Affect Forearm Reactive Hyperemia in Postmenopausal Women on Estradiol Therapy
Author/Authors :
Cho, MM University of Medicine and Dentistry of New Jersey (UMDNJ) - New Jersey Medical School - Department of Obstetrics, Gynecology, and Women’s Health, USA , Hodis, HN USC Keck School of Medicine - Departments of Medicine and Preventive Medicine, Atherosclerosis Research Unit, USA , Mack, WJ USC Keck School of Medicine - Departments of Medicine and Preventive Medicine, Atherosclerosis Research Unit, USA , Roy, S University of Southern California (USC) - Keck School of Medicine - Department of Obstetrics and Gynecology, USA , Paulson, RJ University of Southern California (USC) - Keck School of Medicine - Department of Obstetrics and Gynecology, USA , Li, Y University of Southern California (USC) - Keck School of Medicine - Department of Obstetrics and Gynecology, USA , Stanczyk, FZ University of Southern California (USC) - Keck School of Medicine - Department of Obstetrics and Gynecology, USA
Abstract :
This study aimed at investigating whet-her oral medroxyprogesterone acetate (MPA) or micronized progesterone (P) combined with micronized estradiol (E2) adversely affect endothelial function in postmenopausal women. Materials and Methods: Randomized, doubleblind, crossover trial of MPA or micronized P with oral E2 treatment in menopausal women. Result: Flow-mediated, endothelium-dependent vasodilation of the brachial artery was not significantly affected by short-term administration of E2 alone or E2 combined with cyclic MPA, or E2 combined with cyclic P. Conclusion: Short-term oral E2 treatment of postmenopausal women alone or with cyclic oral MPA or oral P did not affect flow-mediated endothelium- dependent vasodilation.
Keywords :
Medroxyprogesterone acetate , progesterone , estradiol , forearm reactive hyperemia
