Title of article :
The protective effect of thymoquinone, an anti-oxidant and anti-inflammatory agent, against renal injury: A review
Author/Authors :
Ragheb, Ahmed University of Saskatchewan - Royal University Hospital - Department of Medicine, Division of Nephrology, Canada , Attia, Ahmed University of Saskatchewan - Royal University Hospital - Department of Medicine, Division of Nephrology, Canada , Eldin, Walid Shehab University of Saskatchewan - Royal University Hospital - Department of Medicine, Division of Nephrology, Canada , Elbarbry, Fawzy Pacific University - School of Pharmacy, USA , Gazarin, Sana Menofyia University - College of Medicine - Department of General Medicine, Egyp , Shoker, Ahmed University of Saskatchewan - Royal University Hospital - Department of Medicine,Division of Nephrology, Canada
Abstract :
Thymoquinone (TQ), 2-Isopropyl-5-methyl-1, 4-benzoquinone, is one of the most active ingredients of Nigella Sativa seeds. TQ has a variety of beneficial properties including antioxidative and anti-inflammatory activities. Studies have provided original observations on the role of oxidative stress and inflammation in the development of renal diseases such as glomerulonephritis and drug-induced nephrotoxicity. The renoprotective effects of TQ have been demonstrated in animal models. Also, TQ has been used successfully in treating allergic diseases in humans. The aim of this review is to highlight the importance of reactive oxygen species in renal pathophysiology and the intriguing possibility for a role of TQ in the prevention of and/or protection from renal injury in humans.
