Synthesis, characterization, crystal structures, and antibacterial activity of some new 1-(3,4,5-trimethoxybenzoyl)-3-aryl thioureas

Synthesis of some novel 1-(3,4,5-trimethoxy)benzoyl-3-arylthiourea derivatives (1a-o) was accomplished in 2 steps. The synthetic route involves the reaction of 1-(3,4,5-trimethoxy)benzoyl chloride with potassium thiocyanate in 1:1 molar ratio in acetone to afford the corresponding isothiocyante followed by treatment with suitably substituted anilines. The structures of the products were established by elemental analyses,IR, 1 H- and 13C-NMR, and mass spectroscopy and for 1b and 1m from single crystal X-ray diffraction data.All of the synthesized compounds (1a-o) were screened for antibacterial activity against gram positive and gram negative bacterial strains and were found to exhibit low activity towards the tested microorganisms,compared to chloramphenicol, the standard drug.