Synthesis of the 2,4-diphenyl-5-imino-Δ2-1,3,4-thiadiazole Derivatives as Potential Antinociceptive Compounds

In this study, some new derivatives of 2,4-diphenyl-5-imino-Δ2-1,3,4-thiadiazole were prepared by reacting α-chlorobenzal phenylhydrazone derivatives (2a–2h) with potassium thiocyanate to yield 2,4-diphenyl-5-imino-Δ2-1,3,4-thiadiazole derivatives (3a–3h). The structures of the compounds were elucidated by IR, 1H-NMR and elemental analysis. Antinociceptive activity was evaluated using in vivo tests, by means of the hot plate method. Qualitatively, all the compounds exerted a lesser antinociceptive effect compared to acetylsalicylic acid