SYNTHESIS AND BIOLOGICAL EVALUATION OF CERTAIN 2H-PYRAN-2- ONES AND SOME DERIVED 1H-PYRIDIN-2-ONE ANALOGS AS ANTIMICROBIAL AGENTSa

Pyran-2-one and pyridine-2-one analogs are known to be biological versatile compounds possessing variety of pharmacological activities. Some 4-(4-nitrophenyl)-5,6-diphenyl-pyran-2- ones and their lH-pyridin-2-one analogs were synthesized and evaluated for their in vitro antimicrobial activities. The chemistry of the reactions employed for the synthesis of the intermediates and target compounds was discussed. The results revealed that some compounds exhibited promising antibacterial and antifungal activities. Compound 8; 1-hydroxy-4-(4- nitrophenyl)-5,6-diphenyl-lH-pyridin-2-one; showed the most potent broad spectrum antimicrobial activity. l-Methyl-4-(4-nitrophenyl)-5,6-diphenyl-lH-pyridin-2-thione 12; was able to exert weak growth inhibitory effect against the Mycobacterium tuberculosis.