Author/Authors :
Nagarajan, Rajakumar University of California, - Department of Radiological Sciences, USA , Margolis, Daniel University of California - Department of Radiological Sciences, USA , McClure, Tim University of California - Department of Radiological Sciences, USA , Raman, Steve University of California - Department of Radiological Sciences, USA , Thomas, M. Albert University of California - Department of Radiological Sciences, USA
Abstract :
Objective: The major goal of the work was to record three-dimensional magnetic resonance spectroscopic imaging (MRSI) and to compare metabolite ratios between different Gleason scores (GS). Materials and Methods: MRSI localized by endorectal coil-acquired point-resolved spectroscopy was performed in 14 men with prostate cancer of GS 6 (n = 7) and 7 (n = 7) using a 1.5-tesla MRI scanner. Results: The ratio of (choline + creatine)/citrate was increased with an increase of GS, i.e. 0.590 ± 0.171 in the target lesion and 0.321 ± 0.157 in the contralateral region of patients with a GS of 6 as opposed to 1.082 ± 0.432 in the target lesion and 0.360 ± 0.243 in the contralateral region of patients with a GS of 7. Conclusion: Our pilot results demonstrated that MRSI was an additional biochemical tool which is complementary to the current imaging modalities for early diagnosis and therapeutic management of prostate cancer.
Keywords :
Magnetic resonance spectroscopic imaging , Prostate cancer , Choline groups , Citrate , Creatine
