Author/Authors :
Shahrokh Esfahani, Samaneh Isfahan Endocrine and Metabolism Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Tabatabaee, Aliye Isfahan Endocrine and Metabolism Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Aminorroaya, Ashraf Isfahan Endocrine and Metabolism Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Amini, Masoud Isfahan Endocrine and Metabolism Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Feizi, Awat Department of Epidemiology and Biostatistics - Isfahan University of Medical Sciences, Isfahan, Iran , Janghorbani, Mohsen Isfahan Endocrine and Metabolism Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Tabatabaei, Azamosadat Isfahan Endocrine and Metabolism Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Meamar, Rokhsareh Isfahan Clinical Toxicology Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Adibi , Atoosa Isfahan Endocrine and Metabolism Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Abyar, Majid Isfahan Endocrine and Metabolism Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Karimifar, Mozhgan Isfahan Endocrine and Metabolism Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Sajad, Raheleh Isfahan Endocrine and Metabolism Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Salehidoost, Rezvan Isfahan Endocrine and Metabolism Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Faghih Imani, Elham Isfahan Endocrine and Metabolism Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Hovsepian, Silva Isfahan Endocrine and Metabolism Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Sirous, Mehri Department of Radiology - Isfahan University of Medical Sciences, Iran , Aminorroaya Yamini, Sima Department of Engineering and Mathematics - Sheffield Hallam University, Sheffield, UK
Abstract :
The Isfahan Thyroid Cohort Study (ITCS) is one of the few population-based epidemiological studies in Iran that investigates the prevalence and incidence of thyroid disorders including hypothyroidism, hyperthyroidism, goiter, nodule, and iodine status.
Methods: This cohort is located in Isfahan, Iran. The first phase was initiated in 2006 with 2523 participants (1275 males, 1248 females). The participants were selected using multi-stage cluster sampling from the general residents of Isfahan, Iran. The study had two phases (2006 and 2011) and its third stage is planned for 2020–2021.
Results: The prevalence of thyroid function states was euthyroid (89.3%, 95% CI: 88%–90%), overt hypothyroidism (2.8%, 95% CI: 2%‒3%), subclinical hypothyroidism (5.8%, 95% CI: 4%–6%), overt hyperthyroidism (0.8%, 95% CI: 0.4%‒1%), and subclinical hyperthyroidism (0.99%, 95% CI: 0.6%–1%). Hypothyroidism and hyperthyroidism were significantly associated with goiter. The incidence of thyroid dysfunction was reported as follows: overt hypothyroidism (2.7, 95% CI: 1.6–3.7), subclinical hypothyroidism (20.6, 95% CI: 18–23), overt hyperthyroidism (1.9, 95% CI: 1–2.7) and subclinical hyperthyroidism (2.7, 95% CI: 1.6–3.7) per 1000 (person-year).
Conclusion: We assessed the prevalence and incidence of thyroid disorders in Isfahan in the first and second phase, respectively. We are conducting the third phase of the ITCS in order to study the associations between thyroid peroxidase antibody (TPOAb) level and environmental factors such as infection.
