The Importance of Heterocyclic Compounds in the Production of Medicinal Compounds: Synthesis AND Characterization of New Derivatives 5-Amino-1,3,4-thiadiazole-2-thiol

Heterocyclic compounds are of great importance in the production of medicinal compounds. In this study, a new compound (E)–(5-(((5-mercapto 1,3,4-thiadiazole-2-yl)imino)methyl)furan-2-yl-methanol) and its complexes with some transition metal ions Cr(III) and Ni(ll) were synthesized. The structure of the ligand and its complexes were characterized using the molar conductivity, FT-IR, 1H-NMR, and mass spectral techniques. The HyperChem 7.51 program was utilized for theoretical study. The measurements data of Molar conductance reveal that the complexes are non-electrolytes. The ligand acts as a Bidentate in Ni complex coordinating through the oxygen atom of the furan ring and methoxy group and act as tridentate in Cr complex. This data is further supported by the manifestation of a band corresponding to the metal-oxygen and metal-nitrogen stretching vibration at 454–688 cm^-1 and 314-466 cm^-1 in the complexes, respectively. From the spectra data and theoretical study, we suggest a square planer for Ni^+2 complex and octahedral geometry of the Cr^+3 complexes.