Title of article :
Study of Genome, Vaccine and Probable Anti Viral Drugs to Save the World From the Capture of SARS-CoV-2: A Mini-Review
Author/Authors :
Pradhan ، Arun Kumar Centre for Biotechnology - Siksha O Anusandhan (Deemed to be University) , Arakha ، Manoranjan Centre for Biotechnology - Siksha O Anusandhan (Deemed to be University) , Sahoo ، Binay Kumar Institute of Biomedical Sciences - Academia Sinica , Bhattacharya ، Debapriya Centre for Biotechnology - Siksha O Anusandhan (Deemed to be University)
Abstract :
The coronavirus disease 2019 (COVID-19) is a single-stranded RNA (+) virus and causes infectious disease by the viral strain severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Now, COVID-19 has become pandemic, and there are neither potential vaccines nor drugs discovered. Its RNA contains genes for structural (S, E, M, N) and non-structural proteins (PLpro, 3CLpro, RdRp, Hel). Interaction between the S protein of SARS-CoV-2 and the ACE 2 receptor of the host cell plays a vital role in the entry of the virus into the cell. Favipiravir, ribavirin, remdesivir, galidesivir, lopinavir, ritonavir, chloroquine, and hydroxychloroquine are the few effective drugs against SARS-CoV-2. Live attenuated virus (mutant MERS-CoV and SARS-CoV or recombination with another live attenuated virus) can act as vaccine platforms against SARS CoV-2 along with DNA vaccine and subunit vaccine
Keywords :
Coronavirus disease 2019 (COVID , 19) , Severe acute respiratory syndrome coronavirus 2 (SARS , CoV , 2) , Chloroquine , Spike protein , Angiotensin , converting enzyme 2 (ACE 2) receptor , Pandemic
Journal title :
Acta Medica Iranica
Journal title :
Acta Medica Iranica
