Title of article :
The Effects of Intravenous Vitamin C on Stress Response Severity in Abdominal Hysterectomy Following Prolonged Fasting Time
Author/Authors :
Imantalab ، Vali Department of Anesthesiology - Anesthesiology Research Center, Al-Zahra Hospital - Guilan University of Medical Sciences , Mansour Ghanaie ، Mandana Department of Obstetrics and Gynecology - Reproductive Health Research Center, Al-Zahra Hospital, School of Medicine - Guilan University of Medical Sciences , Rafiei Sorouri ، Zahra Department of Obstetrics and Gynecology - Reproductive Health Research Center, Al-Zahra Hospital, School of Medicine - Guilan University of Medical Sciences , Mohammadzadeh Jouryabi ، Ali Department of Anesthesiology - Anesthesiology Research Center, Al-Zahra Hospital - Guilan University of Medical Sciences , Ghazanfar Tehran ، Samaneh Department of Anesthesiology - Anesthesiology Research Center, Al-Zahra Hospital - Guilan University of Medical Sciences , Fayazi ، Haniyeh Sadat Razi Clinical Research Development Unit - Guilan University of Medical Sciences , Biazar ، Gelareh Department of Anesthesiology - Anesthesiology Research Center, Al-Zahra Hospital - Guilan University of Medical Sciences , Noroozshamsi ، Mehdi Department of Anesthesiology - School of Medicine, Anesthesiology Research Center, Alzahra Hospital - Guilan University of Medical Sciences
Abstract :
Background: Inevitable prolonged fasting time before surgery leads to inflammatory reactions, surgery-related stress response, and consequently unfavorable outcomes; thus, developing strategies to mitigate these consequences is crucial. Objectives: In this study, weevaluated the effect of ascorbic acid on stress response reduction in abdominal hysterectomy following prolonged fasting time. Methods: Eligiblewomencandidates for abdominal hysterectomy following prolonged fasting time were enrolled in the study and divided into 2 groups of vitamin C [group C; 1 g intravenously (IV) before surgery] and placebo (group P). Before induction of anesthesia, C-reactive protein (CRP), mean arterial pressure (MAP), heart rate (HR), and blood sugar (BS) were measured and compared between the 2 groups at 4-point times, 24 and 48 hours immediately after extubation. Results: Finally, the data of 80 patients were included for the final analysis. A statistically significant difference was observed between the 2 groups in terms of CRP and BS values in T1 CRP serum levels; at the end of the study, CRP values were 0.5±0.55 and 0.92 ± 0.69 in groups C and P, respectively (P = 0.012), and BS levels were 124.12 ± 18.11 and 152.0 ± 17.36 in groups C and P, respectively (P = 0.0001). However, this significant difference was not observed at T2 regarding CRP (P = 0.145) and BS (P = 0.135), as well as at T3 regarding CRP (P = 0.282) and BS (P = 0.213). However, according to both CRP and BS values, the trend of changes from T0 to T3 was significant in the 2 groups (P 0.0001). Hemodynamic parameters were not significantly different between the 2 groups. No adverse event was reported in the 2 groups. Conclusions:We found that ascorbic acid could induce short-term positive effects in abdominal hysterectomy following prolonged fasting time. Obviously, the optimal dosage, timing, and specific cases that benefit the most from this intervention should be investigated.
Keywords :
Vitamin C , Metabolic Stress Responses , Fasting , Hysterectomy
Journal title :
Anesthesiology and Pain Medicine
Journal title :
Anesthesiology and Pain Medicine
