Single versus Two-Site Phacoemulsification and Mitomycin-C Trabeculectomy

Purpose: To compare the outcomes of single-site versus two-site mitomycin-C (MMC)augmented phacotrabeculectomy.Methods: This matched randomized clinical trial included 34 eyes of 30 patients withvisually significant cataracts and poorly controlled glaucoma. Equal numbers of eyeswere randomly assigned to the single-site and two-site groups. In the single-siteapproach, phacoemulsification was performed under a superior scleral tunnel followedby trabeculectomy. The two-site approach included a temporal clear corneal phacoemulsificationcombined with a separate superior trabeculectomy. MMC 0.2 mg/ml wassimilarly applied for one minute in both groups.Results: Patients were followed for a mean period of 13±1.4 (range, 12 to 15) months.Mean best corrected visual acuity one year after surgery was 0.6±0.4 LogMAR in thesingle-site group and 0.4±0.28 LogMAR in the two-site group (P=0.12). In the single-sitegroup, mean preoperative intraocular pressure (IOP) was 26.4±6.6 mmHg which wasdecreased to 14.8±2.5 mmHg, one year after the operation (P 0.001). Correspondingfigures for the two-site group were 22.9±3.3 and 13.6±1.7 mmHg respectively (P 0.001).At final follow up no significant difference in IOP existed between the study groups.Mean number of anti-glaucoma medications was 0.06±0.24 in the two-site group vs0.43±0.5 in the single-site group (P=0.014). The rate of complications was not different between the study groups (P=1).Conclusions: Both single-site and two-site phacotrabeculectomy improved visual acuitywhich was slightly, but not significantly, better with two-site surgery. Final IOP wascomparable with both techniques; however, the two-site group required fewer antiglaucoma medications.