Author/Authors :
Musilek, Kamil Faculty of Military Health Sciences - Department of Toxicology, CzechRepublic , Musilek, Kamil CharlesUniversity in Prague - Faculty of Pharmacy in Hradec Kralove - Department of Pharmaceutical Chemistry and Drug Control, Czech Republic , Holas, Ondrej CharlesUniversity in Prague - Faculty of Pharmacy in Hradec Kralove - Department of Pharmaceutical Chemistry and Drug Control, Czech Republic , Hambalek, Jan Charles University in Prague - Faculty of Pharmacy in Hradec Kralove - Department of Pharmaceutical Chemistry and Drug Control, Czech Republic , Kuca, Kamil Faculty of Military Health Sciences - Department of Toxicology, Czech Republic , Kuca, Kamil Center of Advanced Studies - Faculty of Military Health Sciences, CzechRepublic , Jun, Daniel Faculty of Military Health Sciences - Department of Toxicology, CzechRepublic , Dohnal, Vlastimil Mendel University of Agriculture and Forestry Brno - Department of Food Technology, Czech Republic , Dolezal, Martin Charles University in Prague - Faculty of Pharmacy in Hradec Kralove - Department of Pharmaceutical Chemistry and Drug Control, Czech Republic
Abstract :
Six AChE reactivators with propane linker were synthesized using modification of currently known synthetic pathways. Their potency to reactivate AChE inhibited by nerve agent tabun and insecticide paraoxonwas tested in vitro. The reactivation efficacies of pralidoxime, HI-6, obidoxime and six synthesized reactivators were compared. According to the results obtained, three reactivators seem to be promising against paraoxon-inhibited AChE. Better results were obtained for bisquaternary substances at least with one oximegroup in position four. None of the tested substances was able to satisfactorily reactivate tabun-inhibited AChE.
Keywords :
Acetylcholinesterase , reactivation , tabun , paraoxon , reactivator , oxime
