Title of article :
Hexahydro-Pyrrolo[1’,2’,5’:3,4,5]Thiazolo[3,4-c]Oxazol-1-ones: New Chiral Tricyclic L-Cysteine and D-Penicillamine Derivatives
Author/Authors :
Melo, Teresa M.V.D. Pinho e University of Coimbra - Department of Chemistry, Portugal , Lopes, Susana M.M. University of Coimbra - Department of Chemistry, Portugal , Gonsalves, António M. d’A. Rocha University of Coimbra - Department of Chemistry, Portugal , Kaczor, Agnieszka University of Coimbra - Department of Chemistry, Portugal , Fausto, Rui University of Coimbra - Department of Chemistry, Portugal , Paixão, José A. University of Coimbra - Department of Physics, Portugal , Beja, Ana Matos University of Coimbra - Department of Physics, Portugal
Abstract :
A simple and efficient approach to the synthesis of the new chiral hexahydropyrrolo[1’,2’,5’:3,4,5]thiazolo[3,4-c]oxazol-1-one ring system is reported. Infrared spectroscopy, quantum-chemical calculations and X-ray analysis allowed the stereochemistry assignment of (2aS,4aR,6aR)-2a,3,4,4a,6,6ahexahydropyrrolo-[1’,2’,5’:3,4,5]thiazolo[3,4-c]oxazol-1-one.
Keywords :
Hexahydro , pyrrolo[1’,2’,5’:3,4,5]thiazolo[3,4 , c]oxazol , 1 , ones , L , Cysteine and D , Penicillamine derivatives, Matrixisolation, Infrared spectroscopy, DFT(B3LYP) , 6 , 311++G(d,p) calculations
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
