RELATIONSHIP OF ADIPONECTIN LEVEL WITH GLYCEMIC STATUS AND LIPID PROFILE IN TYPE 2 DIABETIC MEN

Objective: To determine serum adiponectin level, glycemic status and lipid profile in type 2 diabetic men belonging to Khyber Pakhtunkwa (KPK), and to find any possible relationship between them. Study Design / Methods: Thirty six healthy adult males and thirty six type 2 diabetic males were randomly selected in a cross – sectional study. After an overnight fasting their blood samples were taken and analyzed for serum adiponectin, glycosylated hemoglobin (HbA1c), fasting blood glucose (FBG) and lipid profile including total cholesterol (TC), triglycerides (TG), low – density lipoprotein cholesterol (LDL – C), high – density lipoprotein cholesterol (HDL – C) and very low lipoprotein cholesterol (VLDL – C). Results: Type 2 diabetic males when compared to healthy males showed significantly low levels of serum adiponectin (3.2 ± 1.3 vs. 11.06 ± 2.5, P = 0.01) and HDL – C (32.4 ± 9.6 vs. 42.4 ± 8.6, p = 0.01) and significantly high level of FBG (190.4 ± 83.9 vs. 86.8 ± 16.7, p = 0.01), HbA1c (8.8 ± 1.8 vs. 5.2 ± 0.3, p = 0.01) and LDL – C (137.7 ± 33.4 vs. 115.9 ± 29.4). Serum adiponectin level showed a significant negative correlation with FBG (r – 0.596; p = 0.01), HbA1c (r – 0.695; p = 0.01), TC (r – 0.758; p = 0.01), TG (r – 0.747; p = 0.01) and LDL – C (r – 0.754; p = 0.01) in type 2 diabetic men. Adiponectin also showed a significant positive association with HDL – C in controls (r – 0.948; p = 0.01) and cases with type 2 diabetes (r – 0.860; p = 0.01). Conclusion: Serum adiponectin level is markedly decreased in type 2 diabetic cases. Moreover, it is associated positively with HDL – C and negatively with HbA1c and TG levels. Hypoadiponectinaemia is associated with deranged glycaemic status and lipid profile in men having type 2 diabetes mellitus.