Author/Authors :
La Forgia, D I.R.C.C.S. Istituto Tumori “Giovanni Paolo II” - Diagnosis and Imaging Therapy Department, Bari, Italy , Armenio, A Plastic Surgery Department - I.R.C.C.S. Istituto Tumori “Giovanni Paolo II, Bari, Italy , De Santis, V Plastic Surgery Department - I.R.C.C.S. Istituto Tumori “Giovanni Paolo II, Bari, Italy , Fanizzi, A I.R.C.C.S. Istituto Tumori “Giovanni Paolo II” - Diagnosis and Imaging Therapy Department, Bari, Italy , Maiorella, A Plastic Surgery Department - I.R.C.C.S. Istituto Tumori “Giovanni Paolo II, Bari, Italy , Scattone, A Department of Pathology - I.R.C.C.S. Istituto Tumori “Giovanni Paolo II”, Bari, Italy , Ressa, C.M Plastic Surgery Department - I.R.C.C.S. Istituto Tumori “Giovanni Paolo II, Bari, Italy
Abstract :
Anaplastic large T-cell lymphoma (BI-ALCL) is a rare primitive lymphoma found particularly in women with textured breast implant prostheses, which has been arousing interest in recent years due to its potentially high social impact. The difficult diagnosis together with the increasingly high number of
prosthetic implants worldwide has led to a hypothesize of an underestimation
of its real impact in prosthesis-bearing women. The clinical onset usually
occurs with a cold seroma and disease confined to the prosthetic capsule
while the more advanced stages may involve 1 or more lymph nodes or,
rarely, distant metastases. Early diagnosis is essential as the disease has a
favorable prognosis in over 90% of cases when detected in the early stages
while it often has a poor prognosis in the advanced ones: despite this, the
radiological signs of early disease are still non-specific. This report describes a
case of BI-ALCL confined to the capsule which was studied using all diagnostic techniques in order to highlight its early radiological signs.
Keywords :
Anaplastic large-cell lymphoma , breast magnetic resonance , breast cancer , radiomic analysis , computer-aided diagnosis
