Title of article :
Therapeutic mechanism of 32P application combined with timolol maleate for infantile superficial hemangioma
Author/Authors :
Ma, R.X Department of Pharmacy - Xingtai People's Hospital, Xingtai, China , Li, Z.L Department of Nuclear Medicine - Xingtai People's Hospital, Xingtai, China
Abstract :
Background: This study aims to explore the therapeutic mechanism of 32P application combined with timolol maleate for infantile superficial hemangioma. Materials and Methods: In this study, 60 nude mice were enrolled to establish the transplantation
model of infantile hemangioma in nude mice. They were randomly divided into control
group, administration group and combined administration group, with 20 mice in each
group. The expressions of EGFL7 and VEGF were detected by RT-PCR, and the
expressions of renin and ang II were detected by Western blot. Results: After the
administration of timolol maleate, the expression of EGFL7, VEGF, renin and Ang II
decreased (P < 0.05). The levels of EGFL7, VEGF, renin and Ang II were further down
regulated by combined scheme of 32P application and timolol maleate (P<0.05).
Conclusion: 32P application combined with timolol maleate can improve the
therapeutic effect of infantile superficial hemangioma by inhibiting the expression of vascular endothelial growth factor, renin and angiotensin II.
Keywords :
Hemangioma , timolol maleate , 32P , angiotensin II , vascular endothelial growth factor
Journal title :
International Journal of Radiation Research