Highly (alpha)-Selective Synthesis of Disaccharide Using Glycosyl Bromide by the Promotion of Phosphine Oxide

A simple and practical method for the glycosylation of several acceptors with 2,3,4,6-tetra-O-benzyl-D-glucopyranosyl bromide was established by the promotion of phosphine oxide. The corresponding disaccharides were obtained in high yields with extremely high (alpha)-selectivities under almost neutral condition.