Title of article :
The Role of Th17/Treg Imbalance, FeNO, Eosinophils, IgE and Their Correlation with Lung Function Parameters with Asthma-chronic Obstructive Pulmonary Disease
Author/Authors :
Xie ، Chenli Department of Pulmonary and Critical Care Medicine - Binhaiwan Central Hospital of Dongguan , Xu ، Weixia Department of Pulmonary and Critical Care Medicine - Binhaiwan Central Hospital of Dongguan , Rao ، Shuke Department of Pulmonary and Critical Care Medicine - Binhaiwan Central Hospital of Dongguan , Xie ، Yanshen Department of Pulmonary and Critical Care Medicine - Binhaiwan Central Hospital of Dongguan , Liang ، Qingting Department of Pulmonary and Critical Care Medicine - Binhaiwan Central Hospital of Dongguan , Chen ، Lichong Department of Pulmonary and Critical Care Medicine - Binhaiwan Central Hospital of Dongguan , Yuan ، Weiliang Department of Pulmonary and Critical Care Medicine - Binhaiwan Central Hospital of Dongguan , Xie ، Ying Department of Pulmonary and Critical Care Medicine - Binhaiwan Central Hospital of Dongguan , Li ، Huafeng Department of Pulmonary and Critical Care Medicine - Binhaiwan Central Hospital of Dongguan , Xu ، Guihua Department of Pulmonary and Critical Care Medicine - Binhaiwan Central Hospital of Dongguan
From page :
625
To page :
640
Abstract :
This study explored the link between clinical features, immune markers, and asthma-chronic obstructive pulmonary disease overlap (ACO), aiming to enhance diagnostic precision and tailor treatment. The study included 60 patients per group: COPD patients, ACO patients, and healthy controls. Biological indicators such as fractional exhaled nitric oxide (FeNO), eosinophils, immunoglobulin E (IgE), T helper (Th) 17 cell counts, regulatory T-cell (Treg) counts, and cytokine levels of interleukin-17 (IL-17) and interleukin-10 (IL-10) were measured using standard enzyme-linked immunosorbent assay and flow cytometry techniques. Elevated Th17 cells, IL-17, and Th17/Treg ratio, alongside reduced IL-10 and Treg levels, were observed in COPD and ACO patients. ACO patients showed worse lung function, with a negative correlation between FeNO, Th17 cells, Th17/Treg ratio, IL-17, and lung function indices, and a positive correlation with residual volume/total lung capacity (RV/TLC) ratio. The study suggests that Th17/Treg imbalance, FeNO, eosinophils, and IgE could be key in ACO pathogenesis, potentially aiding early diagnosis and targeted treatment. Future research may utilize these findings to develop preventative and therapeutic strategies for ACO.
Keywords :
Asthma , COPD overlap syndrome , Cytokines , Lung function , Regulatory T cells , Systemic inflammation , Th17 cells
Journal title :
Iranian Journal of Allergy, Asthma and Immunology
Journal title :
Iranian Journal of Allergy, Asthma and Immunology
Record number :
2778094
Link To Document :
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