The protective role of CoQ10 against cisplatin-induced cytotoxicity in male albino mice

This study aimed to investigate the protective effect of CoQ10 against cisplatin-induced cytotoxicity in male albino mice. The study was divided into two phases. In the first phase, the optimum dose of CoQ10 was selected by using gradual concentrations of the coenzyme Q10 (100, 200, 400mg/kg). The concentration of 100mg/kg showed a significant difference in reducing the abnormalities in the sperm heads. In the second stage, the interaction of the optimal concentration of CoQ10 with the mutagenic drug cisplatin [Cis-Diammine Dichloride Platinum] (CDDP) on two treatments (before and after the use of the mutagenic drug) performed to find out the mechanism by which the coenzyme works in preventing or reducing the genotoxic effect of the mutagenic drug CDDP in the event of abnormalities in the heads of the sperm, and both of the interaction treatments had a significant decrease. The results the ability of coenzyme Q10 (CoQ10) to counteract the damage caused by cisplatin by abnormalities in the sperm heads. The interaction treatment (before) was less than the interaction treatment (after) in the rate of abnormalities of the sperm heads. In addition, the results showed that the enzymatic compound has a clear protective role because of its important vital activities in protecting sperm from malformations when given before and after cisplatin.