Insights Into Gene Therapy Innovations for Orthopedic Disorders: A Mini-review

A thorough review of the available scientific works related to the use of gene therapy to address orthopedic disorders was performed. This review highlights the considerable promise of gene therapy in transforming clinical practice in this domain. Orthopedic conditions, including a range of problems, such as spinal fusion failure, disc degeneration, fractures, segmental bone defects, bone tumors, joint disorders, soft-tissue injuries, genetic disorders, and nerve and muscle disorders, often pose significant challenges for traditional surgical or medical treatments. Consequently, a concerted effort has been made to explore gene therapy as a viable alternative. This innovative approach has made significant progress, although several hurdles must be addressed before widespread clinical application in humans. However, gene therapy has considerable potential as a promising treatment option for orthopedic disorders in the 21st century. As gene transfer techniques continue to advance, the potential applications of gene therapy for orthopedic disorders are expected to expand significantly.