Title of article :
In silico studies for the antihypertensive effect of hibiscus acid and related compounds from Hibiscus sabdariffa
Author/Authors :
Zheoat ، Ahmed M. Department of Pharmacy - Al-Manara College for Medical Sciences , Ali ، Ali Muhsen College of Medicine - University of Kerbala , Salem ، Asmaa Sabah Department of Pharmacy - Al-Manara College for Medical Sciences , Hussain ، Zainb Ali Department of Pharmacy - Al-Manara College for Medical Sciences , Alkareem ، Amel Ali Thi-Qar Health Department - Iraqi Ministry of Health , Al-zahy ، Younis Mohamed Atiah Department of Physics - College of Education - Misan University
Abstract :
The use of herbal medicines has been part of human culture for years. For example, hibiscus (Hibiscus sabdariffa) is known for its use in the management of hypertension. Pharmacological studies showed that hibiscus extract is indeed effective in controlling hypertension. This study investigates the effects of acidic constituents in hibiscus extract on several antihypertensive targets using in silico docking techniques. Based on the results, we predict that hibiscus acid may affect human angiotensin-converting enzyme (hACE), potentially responsible for the antihypertensive effect of hibiscus.
Keywords :
Antihypertensive , in silico docking techniques , Hibiscus Acid , Hibiscus sabdariffa , Angiotensin Converting Enzyme (ACE)
Journal title :
Eurasian Chemical Communications
Journal title :
Eurasian Chemical Communications
