Title of article :
Circulating miRNA-106b-5p As a Potential Biomarker for Coronary Artery Disease
Author/Authors :
Azar Bahadori ، Rosita Department of Molecular Genetics - Islamic Azad University, Parand Branch , Shabani ، Dina Department of Biology - Science Faculty - Science and Art University , Arjmandrad ، Elham Department of Molecular and Cellular Sciences - Faculty of Advanced Science and Technology - Islamic Azad University, Tehran Medical Sciences , Kazerani ، Mahsa Department of Cell and Molecular Biology - Faculty of Life Sciences and Biotechnology - Shahid Beheshti University , Rohani ، Mina Department of Clinical Biochemistry - School of Medicine - Mashhad University of Medical Sciences , Ramazani Karim ، Zohreh Department of Clinical Biochemistry - Afzalipour School of Medicine - Kerman University of Medical Sciences , Ali-Kheyl ، Masoud Department of Clinical Biochemistry - Afzalipour School of Medicine - Kerman University of Medical Sciences , Nosratabadi ، Reza Department of Medical Immunology - Afzalipour Faculty of Medicine - Kerman University of Medical Sciences , Pourghadamyari ، Hossein Applied Cellular and Molecular Research Center - Kerman University of Medical Sciences , Zaemi ، Mohammad Ali Department of Medical Genetics - School of Medicine - Tehran University of Medical Sciences
From page :
325
To page :
336
Abstract :
Coronary artery diseases (CAD) represent a significant global health concern and are recognized as a primary contributor to mortality on a worldwide scale. Early diagnosis of CAD is one of promising goal to manage this disorder. Recent investigations have highlighted the pivotal involvement of microRNAs (miRNAs) in diverse health conditions, notably CAD. The principal objective of this investigation was to identify appropriate miRNAs that could be employed for the early detection of CAD. In the present study, we analyzed dataset of CAD (GSE113079) and 100 differentially expressed mRNAs (DEmRNAs) were detected. The miRNAs that have a significant interaction with DEmRNAs were chosen. By computational prediction method, 5 miRNAs (miR-106b-5p, miR-20a-3p, miR-17-3p, miR-146a-5p, and miR-155-3p) were selected. Finally, we assessed the anticipated expression levels of microRNAs in CAD patients and healthy control groups. Our findings revealed a statistically significant elevation solely in the expression level of miR-106b-5p within the CAD group when compared to the control group (p 0.001). Our study demonstrated an elevation in the expression of miR-106b-5p in individuals diagnosed with CAD. This microRNA may be used as a diagnostic biomarker in patients with CAD. However, further investigations are needed to confirm these results.
Keywords :
Circulating miRNA , coronary artery disease , miRNA , mRNA intraction , biomarker
Journal title :
International Journal of Molecular and Cellular Medicine(IJMCM)
Journal title :
International Journal of Molecular and Cellular Medicine(IJMCM)
Record number :
2779476
Link To Document :
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