Author/Authors :
Yu ، Hong Kiangwu Hospital , Wei-ke ، Zeng Sun Yat-sen Memorial Hospital - Sun Yat-sen University , Huai-wu ، Lu Sun Yat-sen Memorial Hospital - Sun Yat-sen University , Chun-ke ، Li Kiangwu Hospital , Hai-qi ، Liang Kiangwu Hospital , Qing-ye ، Chen Kiangwu Hospital
Abstract :
Objectives: In recent years, early screening for endometrial cancer (EC) has received increasing attention. EC screening is recommended to be conducted among high-risk and risk-increasing populations, while the general-risk population, even with symptoms, is not within the scope of screening. This study aims to explore the role of endometrial sampler SAP-1 as a sample-collecting tool to screen EC among patients with general risk. Materials and Methods: From August 2018 to June 2023, 275 patients, who were hospitalized for undergoing hysteroscopy and were confirmed as having a general risk of EC, were enrolled in this retrospective study. Before the procedure, endometrial samples were firstly collected by the method of SAP-1, and then hysteroscopy curettage or electrotomy was conducted to gather endometrial samples. With the pathological results of the latter as the gold standard, the diagnostic efficacy of SAP-1 sampling was analyzed. Results: The sample satisfaction rate of SAP-1 was 91.4%, slightly lower than that by method of hysteroscopy (95.1%), but there was no significant difference between the two methods (P 0.05). The samples of 275 cases were satisfied with both methods. One case of endometrial carcinoma and one case of precancerous lesion were misdiagnosed as normal endometrium with SAP-1 sampling. The sensitivity, specificity and accuracy of SAP-1 in diagnosing endometrial carcinoma and precancerous lesions were 88.2%, 100% and 99.3%, respectively. Conclusions: Applying endometrial sampler SAP-1 to screen EC among women with general risk of EC has high diagnostic efficiency, easy manipulation, high safety, and can be completed in outpatient service with outstanding cost-effectiveness, which as well is worthy of clinical promotion.
Keywords :
Endometrial sampler , Endometrial cancer , Screen , General risk