Title of article :
Diagnostic Accuracy of Ultrasonography for Detection of Intussusception in Children; a Systematic Review and Meta-Analysis
Author/Authors :
Rahmani ، Erfan School of Medicine - Tehran University of Medical Sciences , Amani-Beni ، Reza School of Medicine - Isfahan University of Medical Sciences , Hekmatnia ، Yasaman Islamic Azad University of Medical Science, Sari Branch , Fakhre Yaseri ، Amirhossein School of Medicine - Qazvin University of Medical Sciences , Ahadiat ، Amirabbas Advocate Center for Clinical Research - Ayatollah Yasrebi Hospital , Talebi Boroujeni ، Parham Advanced Diagnostic Interventional Radiology Research Center - Tehran University of Medical Science , Kiani ، Moein School of Medicine - Zanjan University of Medical Sciences , Tavakoli ، Reza School of Medicine - Isfahan University of Medical Sciences , Shafagh ، Ghavam Faculty of Medicine - Iran University of Medical Sciences , Shirazinia ، Matin Faculty of Medicine - Mashhad University of Medical Sciences , Garousi ، Setareh Faculty of Medicine - Mashhad University of Medical Sciences , Mottahedi ، Mehran Faculty of Medicine - Mashhad University of Medical Sciences , Arzaghi ، Mohammad Reza Shahid Beheshti University of Medical Sciences , Pourbagher Benam ، Sasan Faculty of Medicine - Urmia University of Medical Sciences , Rigi ، Amir Islamic Azad University, Zahedan Branch , Salmani ، Amir Sharif University of Technology , Abdollahi ، Zeynab Department of Radiology - School of Medicine - Ahvaz Jundishapur University of Medical Sciences , Karimzade Rokni ، Fateme Faculty of Medical Sciences - Islamic Azad University, Chalus Branch , Nikbakht ، Tara Islamic Azad University, Tehran Medical Branch , Azizi Hassan Abadi ، Saeme Faculty of Medical Sciences - Islamic Azad University, Chalus Branch , Roohinezhad ، Roozbeh Faculty of Medicine - Iran University of Medical Sciences , Masheghati ، Forough School of Medicine - Tabriz University of Medical Sciences , Haririan ، Yas School of Medicine - Shiraz university of Medical Sciences , Darouei ، Bahar School of Medicine - Isfahan University of Medical Sciences , Fayyazishishavan ، Ehsan Department of Biostatistics and Data Science - School of Public Health - University of Texas Health Science Center at Houston (UTHealth) , Manoochehri-Arash ، Niusha Division of Endocrinology, Diabetes and Hypertension - Brigham and Women’s Hospital , Farrokhi ، Mehrdad ERIS Research Institute
Abstract :
Introduction: The diagnosis of intussusception can be challenging in children due to the fact that the findings of clinical evaluations are nonspecific and most of the patients present with unclear history. Therefore, in this systematic review and meta-analysis, we aimed to investigate the diagnostic accuracy of ultrasonography for detection of intussusception and also compare the efficacy of point-of-care ultrasound (POCUS) with radiologist-performed ultrasound (RADUS). Methods: Two independent reviewers systematically searched different online electronic databases including MEDLINE, Scopus, Web of Science, Google Scholar, Embase, and Cochrane from inception to December 1, 2022 to identify published papers reporting accuracy of ultrasonography for diagnosis of intussusception. The quality assessment of the included studies was investigated using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS)-2 tool. Results: A total of 1446 records were retrieved in the initial search of databases. After screening the titles, a total of 344 studies were retrieved for the detailed assessment of full-text. Finally, 37 studies were included in qualitative and quantitative analysis. The pooled sensitivity and specificity of ultrasonography for diagnosis of intussusception were 0.96 (95% CI: 0.95-0.97) and 0.97 (95% CI: 0.97-0.98), respectively. The pooled positive likelihood ratio (PLR) and negative likelihood ratio (NLR) were 24.57 (95% CI: 8.26-73.03) and 0.05 (95% CI: 0.04-0.08), respectively. The area under the hierarchical summary receiver operating characteristic (HSROC) curve was 0.989. Mete-regression showed that there is no significant difference between diagnostic performance of POCUS and RADUS (p = 0.06 and rDOR (diagnostic odds ratio) = 4.38 (95% CI: 0.92-20.89)). Conclusion: This meta-analysis shows that ultrasonography has excellent sensitivity, specificity, and accuracy for diagnosis of intussusception in pediatric patients. Moreover, we found that diagnostic performance of POCUS is similar to that of RADUS for diagnosis of intussusception.
Keywords :
Intussusception , Ultrasonography , Point , of , Care Testing , Diagnostic Imaging , Meta , analysis
Journal title :
Archives of Academic Emergency Medicine (AAEM)
Journal title :
Archives of Academic Emergency Medicine (AAEM)
