Potential use of Nanostructured Lipid Carriers mediated neuronal delivery of Carbamazepine

Carbamazepine (CZB) as a medication for epilepsy and anxiety therapy, presenting a complex pharmacokinetic profile and severe side effects. Therefore, the development of strategies that significantly decrease the side effects and frequency of administration, together with a simple administration, is still a great need. In this respect the use of lipid-based nano systems, such as nanostructured lipid carriers (NLC) and solid lipid nanoparticles (SLN) is highly efficient. In this process, the lipids were used are Cetyl palmitate and Coconut oil to made NLCs, 75°C water bath was prepared; which was included surfactants, Tween80 and Sodium Lauryl Sulfate (SLS), the particles produced by adding the above-mentioned lipids, dissolved in Dichloromethane in this environment. Physiochemical tests were carried out, In vitro drug release studies were performed by HPLC system. Optimized drug-NLCs showed spherical morphology and their average particle size were 170 ± 2.6 nm, PDI of 0.273 ± 0.017. These particles zeta potential and entrapment efficiency were − 23.2 ± 1.2 mV and of 97.1 ± 2.1% respectively. Taken together, the therapeutic effectiveness of CZB was markedly augmented in CZB-NLCs; thereby, NLCs could be appropriate carriers for the delivery of epilepsy medications to the brain with higher drug release potential.