Title of article :
Anti-neoplastic Effects of lt;i gt;Juglans Regia lt;/i gt; L. Green Fruit Pericarp on Breast Cancer Cell Lines
Author/Authors :
Mirzad ، Elsa Department of Biological Science - Faculty of Basic Sciences - University of Kurdistan , Javanmardi ، Mitra Department of Biology - Islamic Azad University, Sanandaj Branch , Haidarizadeh ، Masoud Department of Biological Science - Faculty of Basic Sciences - University of Kurdistan , Abdi ، Mohammad Department of Clinical Biochemistry - Cellular and Molecular Research Center, Research Institute for Health Development, Faculty of Medicine - Kurdistan University of Medical Sciences
From page :
1
To page :
8
Abstract :
Background: Recently, more attention has been paid to the use of complementary medicine in breast cancer (BC) treatment. Juglansgreen fruit pericarp was found to have anti-cancer characteristics. Objectives: We aimed here to assess the possible anti-proliferative effects of methanolic extract of Juglansgreen fruit pericarp in BC cell lines. Methods: MCF-7 and MDA-MB-231 cells were examined with different concentrations of Juglansgreen fruit pericarp extract. The cell viability was investigated using a 3 - 2, 5-diphenyl tetrazolium bromide (MTT) assay. Also, different phases of the cell cycle were analyzed utilizing a flow cytometry method. Finally, the ability of cancer cells to create colonies was studied post-treatment with Juglansgreen fruit pericarp. Results: Our findings showed that the methanol extract has substantial cytotoxicity on MCF-7 and MDA-MB-231 cell lines. We also observed a significant arrest in the G0/G1 phase in cancer cells post-treatment with the methanol extract. Conclusions: In summary, our results introduced a cytotoxic property for Juglansgreen fruit pericarp methanol extract for MCF-7 and MDA-MB-231 cell lines. Future studies are needed to further evaluate its utility as a potential complementary therapy for BC.
Keywords :
Breast Cancer Cell Lines , Cytotoxicity , Juglans RegiaL. Green , Fruit Pericarp , Methanol Extract
Journal title :
Jentashapir Journal of Cellular and Molecular Biology
Journal title :
Jentashapir Journal of Cellular and Molecular Biology
Record number :
2781348
Link To Document :
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