DETERMINATION OF ALBENDAZOLE IN ORAL SUSPENSION

Albendazole is a potent benzimidazole anthelmintic used in the treatment of human intestinal helmintiasis as well as of hydatid cysts and neurocysticercosis. Two analytical methods were standardized for determination of albendazole in pharmaceutical preparations (oral suspension), one by UV direct spectrophotometry at 230 nm usingas solvent 2% sulfuric acid in methanol, and another by HPLC using a Nucleosil® C18 (5µ-4.6×150 mm) Phenomenex® column, and a mobile phase consistingof methanol : 0.05M phosphate buffer (70:30; v/v), UV detection at 254nm and ambient temperature. The methods were applied to simulated and commercially available samples and the results were statistically compared showingthat both methods were accurate and sensitive and there was no significant difference between them.